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Key findings: The formation of paclitaxel crystals in a pharmaceuticalformulation reduces its efficacy.
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However, ethanol inclusion in the pharmaceuticalformulation (to enable drug loading) reduced the in vivo residence.
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The pharmaceuticalformulation of a new anti-tumour agent has often been perceived as the bottleneck in anti-cancer drug development.
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In this work, we developed calibration models for a pharmaceuticalformulation during its three manufacturing stages: blending, compaction and coating.
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Preliminary tested pharmaceuticalformulation applied to EAPB0503 significantly improved its water solubility and will be soon considered for future preclinical in vivo studies.